Manufacturing Split Genentech / Roche & Novartis

Avastin Sales	2010 Q2	2010 Q3	2010 Q4	2011 Q1	2011 Q2	2011 Q3
US Made & Sold	814,872	820,453	800,139	708,539	719,967	688,966
US Made & ex-US Sold	355,742	338,929	415,576	580,981	548,710	587,975
ex-US Made & Sold	426,277	435,325	430,503	307,941	314,028	304,155
Total	1,596,892	1,594,707	1,646,218	1,597,461	1,582,705	1,581,095
US Made & Sold	51%	51%	49%	44%	45%	44%
US Made & ex-US Sold	22%	21%	25%	36%	35%	37%
ex-US Made & Sold	27%	27%	26%	19%	20%	19%

Herceptin Sales	2010 Q2	2010 Q3	2010 Q4	2011 Q1	2011 Q2	2011 Q3
US Made & Sold	406,222	410,563	416,611	409,854	442,903	445,395
US Made & ex-US Sold	312,792	306,085	425,303	423,053	642,670	495,086
ex-US Made & Sold	630,498	584,286	567,396	558,661	474,402	702,416
Total	1,349,512	1,300,934	1,409,310	1,391,568	1,559,975	1,642,898
US Made & Sold	30%	32%	30%	29%	28%	27%
US Made & ex-US Sold	23%	24%	30%	30%	41%	30%
ex-US Made & Sold	47%	45%	40%	40%	30%	43%

Lucentis Sales	2010 Q2	2010 Q3	2010 Q4	2011 Q1	2011 Q2	2011 Q3
US Made & Sold	300,501	326,840	360,911	378,451	409,674	422,335
US Made & ex-US Sold	398,389	418,536	443,773	509,307	533,745	630,474
ex-US Made & Sold	-	-	-	-	-	-
Total	698,890	745,376	804,684	887,757	943,418	1,052,809
US Made & Sold	43%	44%	45%	43%	43%	40%
US Made & ex-US Sold	57%	56%	55%	57%	57%	60%
ex-US Made & Sold	0%	0%	0%	0%	0%	0%

Xolair Sales	2010 Q2	2010 Q3	2010 Q4	2011 Q1	2011 Q2	2011 Q3
US Made & Sold	145,245	165,109	170,001	164,621	167,608	184,837
US Made & ex-US Sold	-	-	-	-	-	-
ex-US Made & Sold	80,632	85,945	93,388	103,133	110,034	126,037
Total	225,878	251,055	263,389	267,754	277,642	310,874
US Made & Sold	64%	66%	65%	61%	60%	59%
US Made & ex-US Sold	0%	0%	0%	0%	0%	0%
ex-US Made & Sold	36%	34%	35%	39%	40%	41%

Total Sales	2010 Q2	2010 Q3	2010 Q4	2011 Q1	2011 Q2	2011 Q3
US Made & Sold	1,666,840	1,722,965	1,747,662	1,661,465	1,740,152	1,741,534
US Made & ex-US Sold	1,081,147	1,063,551	1,284,652	1,513,340	1,725,125	1,713,535
ex-US Made & Sold	1,137,407	1,105,556	1,091,287	969,735	898,464	1,132,608
Total	3,885,394	3,892,072	4,123,601	4,144,540	4,363,741	4,587,677
US Made & Sold	43%	44%	42%	40%	40%	38%
US Made & ex-US Sold	28%	27%	31%	37%	40%	37%
ex-US Made & Sold	29%	28%	26%	23%	21%	25%

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