Manufacturing Split Genentech / Roche & Novartis

Manufacturing Location & Sales – Genentech / Roche & Novartis ($ in 000′s) *

Avastin Sales	2010 Q4	2011 Q1	2011 Q2	2011 Q3	2011 Q4	2012 Q1
US Made & Sold	800,139	708,539	719,967	688,966	684,878	652,824
US Made & ex-US Sold	415,576	580,981	548,710	587,975	375,830	448,037
ex-US Made & Sold	430,503	307,941	314,028	304,155	409,286	401,896
Total	1,646,218	1,597,461	1,582,705	1,581,095	1,469,994	1,502,757
US Made & Sold	49%	44%	45%	44%	47%	43%
US Made & ex-US Sold	25%	36%	35%	37%	26%	30%
ex-US Made & Sold	26%	19%	20%	19%	28%	27%

Herceptin Sales	2010 Q4	2011 Q1	2011 Q2	2011 Q3	2011 Q4	2012 Q1
US Made & Sold	416,611	409,854	442,903	445,395	453,168	456,920
US Made & ex-US Sold	425,303	423,053	642,670	495,086	612,908	523,353
ex-US Made & Sold	567,396	558,661	474,402	702,416	366,695	534,982
Total	1,409,310	1,391,568	1,559,975	1,642,898	1,432,771	1,515,255
US Made & Sold	30%	29%	28%	27%	32%	30%
US Made & ex-US Sold	30%	30%	41%	30%	43%	35%
ex-US Made & Sold	40%	40%	30%	43%	26%	35%

Lucentis Sales	2010 Q4	2011 Q1	2011 Q2	2011 Q3	2011 Q4	2012 Q1
US Made & Sold	360,911	378,451	409,674	422,335	428,884	433,428
US Made & ex-US Sold	443,773	509,307	533,745	630,474	646,131	645,665
ex-US Made & Sold	-	-	-	-	-	-
Total	804,684	887,757	943,418	1,052,809	1,075,015	1,079,092
US Made & Sold	45%	43%	43%	40%	40%	40%
US Made & ex-US Sold	55%	57%	57%	60%	60%	60%
ex-US Made & Sold	0%	0%	0%	0%	0%	0%

Xolair Sales	2010 Q4	2011 Q1	2011 Q2	2011 Q3	2011 Q4	2012 Q1
US Made & Sold	170,001	164,621	167,608	184,837	188,728	185,505
US Made & ex-US Sold	-	-	-	-	-	-
ex-US Made & Sold	93,388	103,133	110,034	126,037	126,184	124,729
Total	263,389	267,754	277,642	310,874	314,911	310,234
US Made & Sold	65%	61%	60%	59%	60%	60%
US Made & ex-US Sold	0%	0%	0%	0%	0%	0%
ex-US Made & Sold	35%	39%	40%	41%	40%	40%

Total Sales	2010 Q4	2011 Q1	2011 Q2	2011 Q3	2011 Q4	2012 Q1
US Made & Sold	1,747,662	1,661,465	1,740,152	1,741,534	1,755,657	1,728,678
US Made & ex-US Sold	1,284,652	1,513,340	1,725,125	1,713,535	1,634,869	1,617,054
ex-US Made & Sold	1,091,287	969,735	898,464	1,132,608	902,165	1,061,607
Total	4,123,601	4,144,540	4,363,741	4,587,677	4,292,691	4,407,339
US Made & Sold	42%	40%	40%	38%	41%	39%
US Made & ex-US Sold	31%	37%	40%	37%	38%	37%
ex-US Made & Sold	26%	23%	21%	25%	21%	24%

* As reported to PDL by its licensees
Totals may not sum due to rounding